Determination of scattering properties and damage thresholds in tissue using ultrafast laser ablation

Chris Martin; Adela Ben-Yakar

doi:10.1117/1.JBO.21.11.115004

30 November 2016 Determination of scattering properties and damage thresholds in tissue using ultrafast laser ablation

Chris Martin, Adela Ben-Yakar

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Journal of Biomedical Optics, Vol. 21, Issue 11, 115004 (November 2016). https://doi.org/10.1117/1.JBO.21.11.115004

Abstract

Ultrafast laser surgery of tissue requires precise knowledge of the tissue’s optical properties to control the extent of subsurface ablation. Here, we present a method to determine the scattering lengths, ℓ_s, and fluence thresholds, F_th, in multilayered and turbid tissue by finding the input energies required to initiate ablation at various depths in each tissue layer. We validated the method using tissue-mimicking phantoms and applied it to porcine vocal folds, which consist of an epithelial (ep) layer and a superficial lamina propia (SLP) layer. Across five vocal fold samples, we found ℓ_s,ep=51.0±3.9 μm, F_th,ep=1.78±0.08 J/cm², ℓ_s,SLP=26.5±1.6 μm, and F_th,SLP=1.14±0.12 J/cm². Our method can enable personalized determination of tissue optical properties in a clinical setting, leading to less patient-to-patient variability and more favorable outcomes in operations, such as femto-LASIK surgery.

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Chris Martin and Adela Ben-Yakar "Determination of scattering properties and damage thresholds in tissue using ultrafast laser ablation," Journal of Biomedical Optics 21(11), 115004 (30 November 2016). https://doi.org/10.1117/1.JBO.21.11.115004

Published: 30 November 2016

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Cited by 8 scholarly publications and 1 patent.

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KEYWORDS

Tissues

Scattering

Laser ablation

Laser tissue interaction

Laser scattering

Laser damage threshold

Tissue optics

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