Use of functional near-infrared spectroscopy to evaluate the effects of anodal transcranial direct current stimulation on brain connectivity in motor-related cortex

Jiaqing Yan; Yun Wei; Yinghua Wang; Gang Xu; Zheng Li; Xiaoli Li

doi:10.1117/1.JBO.20.4.046007

20 April 2015 Use of functional near-infrared spectroscopy to evaluate the effects of anodal transcranial direct current stimulation on brain connectivity in motor-related cortex

Jiaqing Yan, Yun Wei, Yinghua Wang, Gang Xu, Zheng Li, Xiaoli Li

Author Affiliations +

Funded by: National Natural Science Foundation of China, Natural Science Foundation of China

Journal of Biomedical Optics, Vol. 20, Issue 4, 046007 (April 2015). https://doi.org/10.1117/1.JBO.20.4.046007

Abstract

Transcranial direct current stimulation (tDCS) is a noninvasive, safe and convenient neuro-modulatory technique in neurological rehabilitation, treatment, and other aspects of brain disorders. However, evaluating the effects of tDCS is still difficult. We aimed to evaluate the effects of tDCS using hemodynamic changes using functional near-infrared spectroscopy (fNIRS). Five healthy participants were employed and anodal tDCS was applied to the left motor-related cortex, with cathodes positioned on the right dorsolateral supraorbital area. fNIRS data were collected from the right motor-related area at the same time. Functional connectivity (FC) between intracortical regions was calculated between fNIRS channels using a minimum variance distortion-less response magnitude squared coherence (MVDR-MSC) method. The levels of Oxy-HbO change and the FC between channels during the prestimulation, stimulation, and poststimulation stages were compared. Results showed no significant level difference, but the FC measured by MVDR-MSC significantly decreased during tDCS compared with pre-tDCS and post-tDCS, although the FC difference between pre-tDCS and post-tDCS was not significant. We conclude that coherence calculated from resting state fNIRS may be a useful tool for evaluating the effects of anodal tDCS and optimizing parameters for tDCS application.

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Jiaqing Yan, Yun Wei, Yinghua Wang, Gang Xu, Zheng Li, and Xiaoli Li "Use of functional near-infrared spectroscopy to evaluate the effects of anodal transcranial direct current stimulation on brain connectivity in motor-related cortex," Journal of Biomedical Optics 20(4), 046007 (20 April 2015). https://doi.org/10.1117/1.JBO.20.4.046007

Published: 20 April 2015

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