In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography

Anthony M.  D> Lee; Keishi Ohtani; Calum MacAulay; Annette McWilliams; Tawimas Shaipanich; Victor X.  D. Yang; Stephen Lam; Pierre Lane

doi:10.1117/1.JBO.18.5.050501

25 April 2013 In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography

Anthony M. D> Lee, Keishi Ohtani, Calum MacAulay, Annette McWilliams, Tawimas Shaipanich, Victor X. D. Yang, Stephen Lam, Pierre Lane

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Journal of Biomedical Optics, Vol. 18, Issue 5, 050501 (April 2013). https://doi.org/10.1117/1.JBO.18.5.050501

Abstract

For the first time, the use of fiber-optic colorDoppler optical coherence tomography (CDOCT) to mapin vivo the three-dimensional (3-D) vascular network of airwaysegments in human lungs is demonstrated. Visualizingthe 3-D vascular network in the lungs may provide newopportunities for detecting and monitoring lung diseasessuch as asthma, chronic obstructive pulmonary disease, andlung cancer. Our CDOCT instrument employs a rotary fiberopticprobe that provides simultaneous two-dimensional (2-D) real-time structural optical coherence tomography (OCT)and CDOCT imaging at frame rates up to 12.5 frames persecond. Controlled pullback of the probe allows 3-D vascularmapping in airway segments up to 50 mm in length in asingle acquisition. We demonstrate the ability of CDOCT tomap both small and large vessels. In one example, CDOCTimaging allows assignment of a feature in the structural OCTimage as a large (∼1 mm diameter) blood vessel. In a secondexample, a smaller vessel (∼80 μm diameter) that is indistinguishablein the structural OCT image is fully visualized in3-D using CDOCT.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Anthony M. D> Lee, Keishi Ohtani, Calum MacAulay, Annette McWilliams, Tawimas Shaipanich, Victor X. D. Yang, Stephen Lam, and Pierre Lane "In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography," Journal of Biomedical Optics 18(5), 050501 (25 April 2013). https://doi.org/10.1117/1.JBO.18.5.050501

Published: 25 April 2013

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