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1 September 2011 Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation
Nienke Bosschaart, Rosaline Mentink, A. G. J. M. Ton van Leeuwen, Maurice C. G. Aalders, Joke H. Kok
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Journal of Biomedical Optics, Vol. 16, Issue 9, 097003 (September 2011). https://doi.org/10.1117/1.3622629
Abstract
Knowledge of the optical properties of neonatal skin is invaluable when developing new, or improving existing optical techniques for use at the neonatal intensive care. In this article, we present in vivo measurements of the absorption μa and reduced scattering coefficient μs′ of neonatal skin between 450 and 600 nm and assess the influence of age and skin pigmentation on the optical properties. The optical properties were measured using a spatially resolved, steady state diffuse reflectance spectroscopy setup, combined with a modified spatially resolved diffusion model. The method was validated on phantoms with known values for the absorption and reduced scattering coefficient. Values of μa and μs′ were obtained from the skin at four different body locations (forehead, sternum, hand, and foot) of 60 neonates with varying gestational age, postnatal age, and skin pigmentation. We found that μa ranged from 0.02 to 1.25 mm−1 and μs′ was in the range of 1 to 2.8 mm−1 (5th to 95th percentile of the patient population), independent of body location. In contrast to previous studies, no to very weak correlation was observed between the optical properties and gestational maturity, but a strong dependency of the absorption coefficient on postnatal age was found for dark skinned patients.
©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Nienke Bosschaart, Rosaline Mentink, A. G. J. M. Ton van Leeuwen, Maurice C. G. Aalders, and Joke H. Kok "Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation," Journal of Biomedical Optics 16(9), 097003 (1 September 2011). https://doi.org/10.1117/1.3622629
Published: 1 September 2011
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Cited by 40 scholarly publications and 2 patents.
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KEYWORDS
Skin
Optical properties
Diffusion
Absorption
Scattering
In vivo imaging
Tissues
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