In vivo low-coherence spectroscopic measurements of local hemoglobin absorption spectra in human skin

Nienke Bosschaart; Dirk J. Faber; Ton G. van Leeuwen; Maurice C. G. Aalders

doi:10.1117/1.3644497

1 October 2011 In vivo low-coherence spectroscopic measurements of local hemoglobin absorption spectra in human skin

Nienke Bosschaart, Dirk J. Faber, Ton G. van Leeuwen, Maurice C. G. Aalders

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Journal of Biomedical Optics, Vol. 16, Issue 10, 100504 (October 2011). https://doi.org/10.1117/1.3644497

Abstract

Localized spectroscopic measurements of optical properties are invaluable for diagnostic applications that involve layered tissue structures, but conventional spectroscopic techniques lack exact control over the size and depth of the probed tissue volume. We show that low-coherence spectroscopy (LCS) overcomes these limitations by measuring local attenuation and absorption coefficient spectra in layered phantoms. In addition, we demonstrate the first in vivo LCS measurements of the human epidermis and dermis only. From the measured absorption in two distinct regions of the dermal microcirculation, we determine total hemoglobin concentration (3.0±0.5 g/l and 7.8±1.2 g/l) and oxygen saturation.

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Nienke Bosschaart, Dirk J. Faber, Ton G. van Leeuwen, and Maurice C. G. Aalders "In vivo low-coherence spectroscopic measurements of local hemoglobin absorption spectra in human skin," Journal of Biomedical Optics 16(10), 100504 (1 October 2011). https://doi.org/10.1117/1.3644497

Published: 1 October 2011

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KEYWORDS

Absorption

In vivo imaging

Liquid crystals

Skin

Spectroscopy

Blood

Tissue optics

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