Functional photoacoustic microscopy of pH

Mohammad R. Chatni; Junjie Yao; Amos Danielli; Christopher P. Favazza; Konstantin I. Maslov; Lihong V. Wang

doi:10.1117/1.3644495

1 October 2011 Functional photoacoustic microscopy of pH

Mohammad R. Chatni, Junjie Yao, Amos Danielli, Christopher P. Favazza, Konstantin I. Maslov, Lihong V. Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 16, Issue 10, 100503 (October 2011). https://doi.org/10.1117/1.3644495

Abstract

pH is a tightly regulated indicator of metabolic activity. In mammalian systems, an imbalance of pH regulation may result from or result in serious illness. In this paper, we report photoacoustic microscopy (PAM) of a commercially available pH-sensitive fluorescent dye (SNARF-5F carboxylic acid) in tissue phantoms. We demonstrated that PAM is capable of pH imaging in absolute values at tissue depths of up to 2.0 mm, greater than possible with other forms of optical microscopy.

Citation Download Citation

Mohammad R. Chatni, Junjie Yao, Amos Danielli, Christopher P. Favazza, Konstantin I. Maslov, and Lihong V. Wang "Functional photoacoustic microscopy of pH," Journal of Biomedical Optics 16(10), 100503 (1 October 2011). https://doi.org/10.1117/1.3644495

Published: 1 October 2011

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
4 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY