Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

Turgut Durduran; Chao Zhou; Erin M. Buckley; Meeri N. Kim; Guoqiang Yu; Regine Choe; J. William Gaynor; Thomas L. Spray; Suzanne M. Durning; Stefanie E. Mason; Lisa M. Montenegro; Susan C. Nicolson; Robert A. Zimmerman; Mary E. Putt; Jiongjiong Wang; Joel H. Greenberg; John A. Detre; Arjun G. Yodh; Daniel J. Licht

doi:10.1117/1.3425884

1 May 2010 Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

Turgut Durduran, Chao Zhou, Erin M. Buckley, Meeri N. Kim, Guoqiang Yu, Regine Choe, J. William Gaynor, Thomas L. Spray, Suzanne M. Durning, Stefanie E. Mason, Lisa M. Montenegro, Susan C. Nicolson, Robert A. Zimmerman, Mary E. Putt, Jiongjiong Wang, Joel H. Greenberg, John A. Detre, Arjun G. Yodh, Daniel J. Licht

Author Affiliations +

Journal of Biomedical Optics, Vol. 15, Issue 3, 037004 (May 2010). https://doi.org/10.1117/1.3425884

Abstract

We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBF_DCS); and oxygen metabolism (rCMRO₂). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF_ASL-MRI, n=12) cross-validate rCBF_DCS against rCBF_ASL-MRI, showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Turgut Durduran, Chao Zhou, Erin M. Buckley, Meeri N. Kim, Guoqiang Yu, Regine Choe, J. William Gaynor, Thomas L. Spray, Suzanne M. Durning, Stefanie E. Mason, Lisa M. Montenegro, Susan C. Nicolson, Robert A. Zimmerman, Mary E. Putt, Jiongjiong Wang, Joel H. Greenberg, John A. Detre, Arjun G. Yodh, and Daniel J. Licht "Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects," Journal of Biomedical Optics 15(3), 037004 (1 May 2010). https://doi.org/10.1117/1.3425884

Published: 1 May 2010

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
10 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY