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1 May 2010 Speckle fluctuation spectroscopy of intracellular motion in living tissue using coherence-domain digital holography
Kwan Jeong, John J. Turek, David D. Nolte
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Journal of Biomedical Optics, Vol. 15, Issue 3, 030514 (May 2010). https://doi.org/10.1117/1.3456369
Abstract
Dynamic speckle from 3-D coherence-gated optical sections provides a sensitive label-free measure of cellular activity up to 1 mm deep in living tissue. However, specificity to cellular functionality has not previously been demonstrated. In this work, we perform fluctuation spectroscopy on dynamic light scattering captured using coherence-domain digital holography to obtain the spectral response of tissue that is perturbed by temperature, osmolarity, and antimitotic cytoskeletal drugs. Different perturbations induce specific spectrogram response signatures that can show simultaneous enhancement and suppression in different spectral ranges.
©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Kwan Jeong, John J. Turek, and David D. Nolte "Speckle fluctuation spectroscopy of intracellular motion in living tissue using coherence-domain digital holography," Journal of Biomedical Optics 15(3), 030514 (1 May 2010). https://doi.org/10.1117/1.3456369
Published: 1 May 2010
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KEYWORDS
Speckle
Digital holography
Tissue optics
Tissues
Tumors
Holograms
Spectroscopy
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