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1 January 2010 Detection of vesicant-induced upper airway mucosa damage in the hamster cheek pouch model using optical coherence tomography
Marie J. Hammer-Wilson, Vi Nguyen, Woonggyu Jung, Yeh-Chan Ahn, Zhongping Chen, Petra B. B. Wilder-Smith D.D.S.
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Journal of Biomedical Optics, Vol. 15, Issue 1, 016017 (January 2010). https://doi.org/10.1117/1.3309455
Abstract
Hamster cheek pouches were exposed to 2-chloroethyl ethyl sulfide [CEES, half-mustard gas (HMG)] at a concentration of 0.4, 2.0, or 5.0 mg/ml for 1 or 5 min. Twenty-four hours post-HMG exposure, tissue damage was assessed by both stereomicrography and optical coherence tomography (OCT). Damage that was not visible on gross visual examination was apparent in the OCT images. Tissue changes were found to be dependent on both HMG concentration and exposure time. The submucosal and muscle layers of the cheek pouch tissue showed the greatest amount of structural alteration. Routine light microscope histology was performed to confirm the OCT observations.
©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Marie J. Hammer-Wilson, Vi Nguyen, Woonggyu Jung, Yeh-Chan Ahn, Zhongping Chen, and Petra B. B. Wilder-Smith D.D.S. "Detection of vesicant-induced upper airway mucosa damage in the hamster cheek pouch model using optical coherence tomography," Journal of Biomedical Optics 15(1), 016017 (1 January 2010). https://doi.org/10.1117/1.3309455
Published: 1 January 2010
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KEYWORDS
Optical coherence tomography
Tissues
Blistering agents
Tissue optics
Lung
Scanning electron microscopy
Visualization
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