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13 March 2024 Microsecond-scale mid-infrared energy deposition (MIRED) spectroscopic imaging
Jiaze Yin, Cheyenne Teng, Christian Pfluegl, Ji-Xin Cheng
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Proceedings Volume PC12855, Advanced Chemical Microscopy for Life Science and Translational Medicine 2024; PC128550L (2024) https://doi.org/10.1117/12.3003536
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
The mid-infrared photothermal microscope enables super-resolution imaging of living systems in water. However, the slow tuning of the laser limits spectroscopic imaging output to one color per second. To solve this, we developed a microsecond-scale spectroscopic detection scheme with a fast-tuning quantum cascade laser array. Each laser in the array emits at a slightly different wavelength, operating independently. A sequential emission from 32 lasers is completed within 4 microseconds. The absorption spectrum is acquired by capturing the temperature rise curve and calculating the first derivative. This improved spectroscopic imaging covers 150 cm-1 wavenumbers at 5 cm-1 resolution in one second, enabling real-time multiplexed molecular analysis.
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Jiaze Yin, Cheyenne Teng, Christian Pfluegl, and Ji-Xin Cheng "Microsecond-scale mid-infrared energy deposition (MIRED) spectroscopic imaging", Proc. SPIE PC12855, Advanced Chemical Microscopy for Life Science and Translational Medicine 2024, PC128550L (13 March 2024); https://doi.org/10.1117/12.3003536
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KEYWORDS
Imaging spectroscopy
Mid-IR
Spectroscopy
Quantum cascade lasers
Image processing
Infrared imaging
Pulse signals
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