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13 March 2024 Label-free, multi-scale imaging of mitochondrial and metabolic function in living tissues
Irene Georgakoudi
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Proceedings Volume PC12854, Label-free Biomedical Imaging and Sensing (LBIS) 2024; PC128540M (2024) https://doi.org/10.1117/12.2690222
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
This presentation will highlight the unique opportunities to assess metabolic and mitochondrial function and/or dysfunction afforded by label-free, two photon imaging. The high resolution of two-photon images enables unique assessments of the spatiotemporal heterogeneity of metabolic and mitochondrial dysfunction, which is recognized increasingly as a significant driver of events that determine the development and/or treatment response of numerous diseases. The combined use of readouts from fluorescence intensity and lifetime images yields sensitivity and specificity to metabolic function changes. Examples to highlight such measurements in the context of cancer, vitiligo, and neurodegeneration will be presented.
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Irene Georgakoudi "Label-free, multi-scale imaging of mitochondrial and metabolic function in living tissues", Proc. SPIE PC12854, Label-free Biomedical Imaging and Sensing (LBIS) 2024, PC128540M (13 March 2024); https://doi.org/10.1117/12.2690222
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KEYWORDS
Mitochondria
Tissues
Autofluorescence
Two photon imaging
Fluorophores
Image resolution
Neurodegeneration
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