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13 March 2024 Label-free in vivo imaging using photon absorption remote sensing
James A. Tummon Simmons, Sarah J. Werezak, Benjamin R. Ecclestone, James E. D. Tweel, Parsin Haji Reza
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Proceedings Volume PC12854, Label-free Biomedical Imaging and Sensing (LBIS) 2024; PC128540K (2024) https://doi.org/10.1117/12.3002936
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Vascular imaging is an essential tool for understanding tissue health in the diagnosis and treatment of disease, especially for applications in cancer and ophthalmology. This work explores the application of Photon Absorption Remote Sensing (PARS) microscopy to several established in vivo vasculature models including chicken embryo and mouse ear. Significant system improvements are presented which have enabled the repeatable acquisition of images that are larger, require less scan time, and capture detailed absorption contrast of both radiative and non-radiative relaxation. The presented work demonstrates PARS as a promising platform for future clinical evaluation of disease pathology and treatment efficacy.
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James A. Tummon Simmons, Sarah J. Werezak, Benjamin R. Ecclestone, James E. D. Tweel, and Parsin Haji Reza "Label-free in vivo imaging using photon absorption remote sensing", Proc. SPIE PC12854, Label-free Biomedical Imaging and Sensing (LBIS) 2024, PC128540K (13 March 2024); https://doi.org/10.1117/12.3002936
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KEYWORDS
In vivo imaging
Light absorption
Photodetectors
Remote sensing
Absorption
Imaging systems
Optical scanning systems
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