Multiscale multicontrast photoacoustic computed tomography

Lei Li

doi:10.1117/12.3011383

13 March 2024 Multiscale multicontrast photoacoustic computed tomography

Lei Li

Proceedings Volume PC12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC1283605 (2024) https://doi.org/10.1117/12.3011383
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

A stand-alone single-impulse photoacoustic computed tomography (PACT) system has been built, which successfully mitigates these limitations by integrating high spatiotemporal resolution, deep penetration, and full-view fidelity, as well as anatomical, dynamical, and functional contrasts. Based on hemoglobin absorption contrast, the whole-body dynamics and large scale brain functions of rodents have been imaged in real time. The absorption contrast between cytochrome and lipid has enabled PACT to resolve MRI-like whole brain structures. Taking advantage of the distinct absorption signature of melanin, unlabeled circulating melanoma cells have been tracked in real time in vivo. Genetically encoded photochromic proteins benefit PACT in detection sensitivity and specificity. The unique photoswitching characteristics of different photochromic proteins allow quantitative multi-contrast imaging at depths. A split version of the photochromic protein has permitted PA detection of protein-protein interactions in deep-seated tumors. As a rapidly evolving imaging technique, multiscale multicontrast PACT promises pre-clinical applications and clinical translation.

Conference Presentation

Citation Download Citation

Lei Li "Multiscale multicontrast photoacoustic computed tomography", Proc. SPIE PC12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC1283605 (13 March 2024); https://doi.org/10.1117/12.3011383

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