In vivo endoscopic polarization sensitive OCT for the quantification of airway smooth muscle in airway disease and healthy volunteers

Tatiana Soldati; Sofi M. Vassileva; Margherita Vaselli; Kirsten A. Kalverda; Pieta C. Wijsman; Jouke T. Annema; Peter I. Bonta; Johannes F. de Boer

doi:10.1117/12.3005436

13 March 2024 In vivo endoscopic polarization sensitive OCT for the quantification of airway smooth muscle in airway disease and healthy volunteers

Tatiana Soldati, Sofi M. Vassileva, Margherita Vaselli, Kirsten A. Kalverda, Pieta C. Wijsman, Jouke T. Annema, Peter I. Bonta, Johannes F. de Boer

Author Affiliations +

Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC128301Q (2024) https://doi.org/10.1117/12.3005436
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Currently, no diagnostic method exists to visualize and measure the airway smooth muscle (ASM) in vivo. Endoscopic Polarization Sensitive Optical Coherence Tomography (PS-OCT) has the potential to detect and quantify the ASM, by assessing tissue birefringence. We performed in vivo PS-OCT in patients (n=17) with airway diseases (asthma and interstitial lung disease) and one healthy volunteer. PS-OCT images were acquired with an in-house built distal scanning catheter (1.35mm), which allowed circumferential scan of the airways at 52 fps B-scan rate. We demonstrated PS-OCT to be a minimally invasive technique to assess ASM thickness in diseased airways relative to healthy subjects.

Conference Presentation

Citation Download Citation

Tatiana Soldati, Sofi M. Vassileva, Margherita Vaselli, Kirsten A. Kalverda, Pieta C. Wijsman, Jouke T. Annema, Peter I. Bonta, and Johannes F. de Boer "In vivo endoscopic polarization sensitive OCT for the quantification of airway smooth muscle in airway disease and healthy volunteers", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC128301Q (13 March 2024); https://doi.org/10.1117/12.3005436

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