Utilizing shortwave infrared fluorescence imaging (SWIRFI) for targeted preclinical tumor resection

Ben Mc Larney; Magdalena Skubal; Mijin Kim; Jason Lewis; Daniel Heller; Jan Grimm

doi:10.1117/12.2692579

13 March 2024 Utilizing shortwave infrared fluorescence imaging (SWIRFI) for targeted preclinical tumor resection

Ben Mc Larney, Magdalena Skubal, Mijin Kim, Jason Lewis, Daniel Heller, Jan Grimm

Proceedings Volume PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; PC128250L (2024) https://doi.org/10.1117/12.2692579
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

In this work we highlight the preclinical optimization of targeted tumor fluorophores for delineation. We utilize shortwave infrared fluorescence imaging (SWIRFI) under non-gated or filtered ambient lighting conditions to achieve a symbiotic fluorescence guided surgery ecosystem for unprecedented tumor contrast. With two commercially available targeted dyes we readily achieved tumor to muscle ratios in the ranges of 40 to 80, with exposure times as low as 1 ms within ANSI limited laser exposures. We highlight the metrics which can be used to quantify this contrast and signal, and further highlight the need for standardized metrics in academic and industry settings.

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Citation Download Citation

Ben Mc Larney, Magdalena Skubal, Mijin Kim, Jason Lewis, Daniel Heller, and Jan Grimm "Utilizing shortwave infrared fluorescence imaging (SWIRFI) for targeted preclinical tumor resection", Proc. SPIE PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, PC128250L (13 March 2024); https://doi.org/10.1117/12.2692579

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KEYWORDS

Tumors

Dyes

Resection

Fluorescence imaging

Short wave infrared radiation

Liver

Near infrared

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