CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume PC12822 > Article
Presentation
13 March 2024 Antimicrobial blue light activatable optical-tympanostomy tube: a novel alternative to control tympanostomy tube otorrhea
Carolina dos Anjos, Vishakha Sabharwal, Soroush Shabahang, Gizem Dilara Ozdemir, Loc Truong, Yazdani B. Shaik-Dasthagirisaheb, Stephen Pelton, Tianhong Dai
Author Affiliations +
Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC128220J (2024) https://doi.org/10.1117/12.3003562
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Tympanostomy tube otorrhea (TTO) is a frequent complication associated with tympanostomy tube (TT) insertion in young children. Despite the standard treatment using topical antibiotics, TTO is often persistent or recurrent due to biofilm development on TT. In this study, we developed a novel antimicrobial blue light (aBL; 405nm) activatable Optical-TT, which emits aBL from the entire TT surface to kill major otopathogens in biofilms on TT. Our preliminary results showed that the Optical-TT activated by aBL led to over 2.5-log10 CFU reduction in 120 h-old H. influenzae films and 48 h-old P. aeruginosa biofilms formed on TT after 30 J/cm2 aBL and in 48 h-old S. aureus biofilms formed on TT after 60 J/cm2, implying the potential of aBL-activable Optical-TT in the management of TTO. Animal studies using a chinchilla model of TTO are currently underway.
Conference Presentation
© (2024) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Carolina dos Anjos, Vishakha Sabharwal, Soroush Shabahang, Gizem Dilara Ozdemir, Loc Truong, Yazdani B. Shaik-Dasthagirisaheb, Stephen Pelton, and Tianhong Dai "Antimicrobial blue light activatable optical-tympanostomy tube: a novel alternative to control tympanostomy tube otorrhea", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC128220J (13 March 2024); https://doi.org/10.1117/12.3003562
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Biofilms
Optical surfaces
Animal model studies
Animals
In vitro testing
Light emitting diodes
Therapeutics
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top