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13 March 2024 Revolutionizing wound treatment: a wearable optical platform for multidrug-resistant infections
Yanfang Feng, Manuel Alejandro Triana Valencia, Shakir Khan, Yajie Dong, Tayyaba Hasan
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Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC128220D (2024) https://doi.org/10.1117/12.3001700
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
We developed a wearable antimicrobial photodynamic therapy (aPDT) device that can sterilize multidrug-resistant (MDR) wound infections safely and effectively at the point of care. This aPDT platform was developed by leveraging advanced optical device fabrication techniques and evaluated by a combination of in vitro, ex vivo, and in vivo bacterial wound infection models. Throughout all the wound infection models, this aPDT platform is capable to inactivate at least 90% of MDR pathogens in the wound infections, showing potential to generalize the application of aPDT in the clinic for MDR infection prevention and treatment for chronic wounds.
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Yanfang Feng, Manuel Alejandro Triana Valencia, Shakir Khan, Yajie Dong, and Tayyaba Hasan "Revolutionizing wound treatment: a wearable optical platform for multidrug-resistant infections", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC128220D (13 March 2024); https://doi.org/10.1117/12.3001700
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KEYWORDS
Pathogens
Point-of-care devices
In vitro testing
In vivo imaging
Laser systems engineering
LED lighting
Light emitting diodes
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