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12 August 2023 Optical coherence tomography and polymeric particles: a combination for three-dimensional thermal imaging in tissues
T. Muñoz-Ortiz, I. Alayeto, J. Lifante, M. C. Iglesias-de la Cruz, D. Ortgies, R. Marin, E. Martín Rodríguez, G. Lifante-Pedrola, J. Rubio, D. Jaque
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Proceedings Volume PC12622, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials VI; PC126220P (2023) https://doi.org/10.1117/12.2673839
Event: SPIE Optical Metrology, 2023, Munich, Germany
Abstract
We propose the combination of polyN-isopropylacrylamide (PNIPAM) particles and optical coherence tomography (OCT) to overcome the main limitations of current nanothermometry for medical purposes. We demonstrate that PNIPAM particles can behave as temperature-sensitive contrast agents in OCT thanks to their structural phase transition at 32 °C, resulting in changes in the refractive index that make their OCT contrast temperature-dependent. Simple experiments have been conducted to demonstrate the feasibility of this approach for three-dimensional imaging of phantom tissues subjected to photothermal processes. The results included in this work constitute an alternative route towards facile incorporation of nanothermometry into the clinical world.
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T. Muñoz-Ortiz, I. Alayeto, J. Lifante, M. C. Iglesias-de la Cruz, D. Ortgies, R. Marin, E. Martín Rodríguez, G. Lifante-Pedrola, J. Rubio, and D. Jaque "Optical coherence tomography and polymeric particles: a combination for three-dimensional thermal imaging in tissues", Proc. SPIE PC12622, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials VI, PC126220P (12 August 2023); https://doi.org/10.1117/12.2673839
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KEYWORDS
3D image processing
Optical coherence tomography
Particles
Tissues
Thermography
Polymers
Refractive index
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