Using zinc-oxide nanowires: sun would cure ulcerating cancer wounds

Ashkan Zandi; Ali Adibi

doi:10.1117/12.2661607

17 March 2023 Using zinc-oxide nanowires: sun would cure ulcerating cancer wounds

Ashkan Zandi, Ali Adibi

Proceedings Volume PC12431, Photonic and Phononic Properties of Engineered Nanostructures XIII; PC1243105 (2023) https://doi.org/10.1117/12.2661607
Event: SPIE OPTO, 2023, San Francisco, California, United States

Abstract

Among all the new cancer treatment modalities, photodynamic therapy (PDT) is a promising method for its lower systemic toxicity, lower side effects, and improved tumor selectivity. PDT is based on activating light-absorbing molecules, often known as photosensitizers (PS). Here we introduce a new zinc-oxide nanowire (ZnONW) hydrogel and transparent wound healing antibacterial patch to treat superficial ulcerating cancer wounds. Active embedded ZnONWs in hydrogel/patch with the band gap of 3.37 eV would absorb ultraviolet radiations, and after a series of photochemical reactions in the aqueous environment of hydrogel/wound would generate ROS. The produced ROS triggers a series of cellular and molecular processes that have an antibacterial effect as well as an impact on the growth cycle of cancer cells. According to our study, using this hydrogel/patch in conjunction with conventional chemotherapy could speed up the healing of malignant wounds by a factor of two.

Conference Presentation

Citation Download Citation

Ashkan Zandi and Ali Adibi "Using zinc-oxide nanowires: sun would cure ulcerating cancer wounds", Proc. SPIE PC12431, Photonic and Phononic Properties of Engineered Nanostructures XIII, PC1243105 (17 March 2023); https://doi.org/10.1117/12.2661607

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