High speed low frequency Raman spectroscopy and microscopy

Randy A. Bartels; David Smith; Siddarth Shivkumar; Jeffrey Field; Hervé Rigneault

doi:10.1117/12.2650733

17 March 2023 High speed low frequency Raman spectroscopy and microscopy

Randy A. Bartels, David Smith, Siddarth Shivkumar, Jeffrey Field, Hervé Rigneault

Proceedings Volume PC12406, Real-time Measurements, Rogue Phenomena, and Single-Shot Applications VIII; PC1240609 (2023) https://doi.org/10.1117/12.2650733
Event: SPIE LASE, 2023, San Francisco, California, United States

Abstract

Raman spectra provide a rich and powerful label-free probe of biological systems. While the narrow spectral features make Raman spectroscopy extremely attractive, the weak strength of Raman scattering makes it difficult to deeply in many situations. Low frequency Raman scattering spectroscopy provides the potential for probing macromolecular and local material properties. Until recently, the acquisition of such low frequency Raman spectra has been limited by technical challenges. We will discuss newly developed tools that allow for high-speed time-domain Raman spectroscopy of low and fingerprint region Raman spectra. Imaging performance and robustness of the signal to scattering will also be discussed.

Conference Presentation

Citation Download Citation

Randy A. Bartels, David Smith, Siddarth Shivkumar, Jeffrey Field, and Hervé Rigneault "High speed low frequency Raman spectroscopy and microscopy", Proc. SPIE PC12406, Real-time Measurements, Rogue Phenomena, and Single-Shot Applications VIII, PC1240609 (17 March 2023); https://doi.org/10.1117/12.2650733

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