Optical coherence elastography on clinical samples of gastric cancer shows promise for assessing alteration of mechanical properties with onset of disease (Conference Presentation)

Travis W. Sawyer; Graham Spicer; Stephen Mead; Massimiliano Di Pietro; Ashraf Sanduka; Tae Kim; Makenna Aitken; Faith Rice; Bhaskar Banerjee; Hemanth Gavini; Aws Alameri; Sarah E. Bohndiek; Jennifer K. Barton

doi:10.1117/12.2652958

16 March 2023 Optical coherence elastography on clinical samples of gastric cancer shows promise for assessing alteration of mechanical properties with onset of disease (Conference Presentation)

Travis W. Sawyer, Graham Spicer, Stephen Mead, Massimiliano Di Pietro, Ashraf Sanduka, Tae Kim, Makenna Aitken, Faith Rice, Bhaskar Banerjee, Hemanth Gavini, Aws Alameri, Sarah E. Bohndiek, Jennifer K. Barton

Author Affiliations +

Proceedings Volume PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023; PC123910Y (2023) https://doi.org/10.1117/12.2652958
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Gastric cancer is a deadly disease afflicting millions annually, with overall poor prognosis due to lack of effective detection and localization tools. Optical coherence elastography is a promising technique for assessing mechanical properties of tissue, which could be valuable for early detection of stomach cancer, which can influence the stiffness of tissue. We evaluate the suitability of OCE for assessing mechanical properties of tissue for clinical specimens of normal and stomach cancer, finding that the stiffness is increased by up to twofold in cases of cancer. These results show promise for validating OCE as a tool for localizing stomach cancer.

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Travis W. Sawyer, Graham Spicer, Stephen Mead, Massimiliano Di Pietro, Ashraf Sanduka, Tae Kim, Makenna Aitken, Faith Rice, Bhaskar Banerjee, Hemanth Gavini, Aws Alameri, Sarah E. Bohndiek, and Jennifer K. Barton "Optical coherence elastography on clinical samples of gastric cancer shows promise for assessing alteration of mechanical properties with onset of disease (Conference Presentation)", Proc. SPIE PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, PC123910Y (16 March 2023); https://doi.org/10.1117/12.2652958

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KEYWORDS

Cancer

Coherence (optics)

Elastography

Tissues

Tissue optics

Endoscopy

Tumors

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