16 March 2023Uncovering the long-term effects of mRNA COVID-19 vaccinations on platelets by high-speed optical imaging on a chip (Conference Presentation)
1The Univ. of Tokyo (Japan) 2The Univ. of Tokyo Hospital (Japan) 3CYBO, Inc. (Japan) 4Central Blood Institute, Japanese Red Cross Society (Japan) 5National Heart, Lung, and Blood Institute, National Institutes of Health (United States) 6Univ. of Virginia (United States) 7Wuhan Univ. (China)
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There is widespread concern about the safety of COVID-19 vaccinations related to platelet hyperactivity. However, their long-term influence on platelet activity remains unknown. We address this issue by applying a high-speed bright-field microscope based on optical frequency-division multiplexing and microfluidics for massive image-based analysis. We performed image-based single-cell profiling and temporal monitoring of circulating platelet aggregates in the blood samples of healthy human participants before and after they received three vaccination doses over a nearly one-year period. The results demonstrate no significant or persistent change in platelet activity after vaccine doses.
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