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16 March 2023 Label-free plasmonic imaging for quantitative analysis of transparent nanoscale objects (Conference Presentation)
Wei-Chuan Shih
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Proceedings Volume PC12390, High-Speed Biomedical Imaging and Spectroscopy VIII; PC123900F (2023) https://doi.org/10.1117/12.2655972
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Label-free optical observation of transparent nano-objects is challenging. Here, we demonstrate PlAsmonic NanO-apeRture lAbel-free iMAging (PANORAMA) that addresses existing issues for both SPR and LSPR imaging. PANORAMA involves a standard commercial bright-field microscope without the need for laser or interferometric detection. PANORAMA can image, size, count, and monitor a single polystyrene nanoparticle down to 25 nm at a millisecond timescale. The extrapolated size limit of detection is sub-10 nm. Higher imaging speed is achievable with high-speed cameras. Molecular imaging is envisioned with functionalized substrates for single nanoparticle analysis for extracellular vesicles (e.g., exosomes) and pathogens (e.g., viruses).
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Wei-Chuan Shih "Label-free plasmonic imaging for quantitative analysis of transparent nanoscale objects (Conference Presentation)", Proc. SPIE PC12390, High-Speed Biomedical Imaging and Spectroscopy VIII, PC123900F (16 March 2023); https://doi.org/10.1117/12.2655972
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KEYWORDS
Panoramic photography
Nanoparticles
Plasmonic imaging
Quantitative analysis
Plasmonics
Biological research
Microscopes
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