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9 March 2023 Enabling quantitative shear wave elastography in conventional optical coherence tomography in vivo
Ginger J. Schmidt, Taylor M. Cannon, Brett E. Bouma, Néstor Uribe-Patarroyo
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Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC1236716 (2023) https://doi.org/10.1117/12.2653002
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Existing conventional OCT systems lack the ability to robustly measure biomechanical contrast. While many wave-based elastography methods have been developed for imaging stiffness, they also have limitations that make adaptation to imaging in vivo infeasible. While passive elastography doesn’t require coherence, we also cannot derive quantitative mechanical properties without it. Similarly, it been assumed that reverberant elastography also requires coherence. However, through benchtop raster-scanning and balloon catheter radially-scanning OCT, we demonstrate that it is possible to adapt reverberant elastography for unsynchronized, free-running excitation to obtain cross-sectional shear wave elastography at speeds compatible with in vivo applications.
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Ginger J. Schmidt, Taylor M. Cannon, Brett E. Bouma, and Néstor Uribe-Patarroyo "Enabling quantitative shear wave elastography in conventional optical coherence tomography in vivo", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC1236716 (9 March 2023); https://doi.org/10.1117/12.2653002
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KEYWORDS
Elastography
In vivo imaging
Optical coherence tomography
Raster graphics
Spatial coherence
Pathology
Spherical lenses
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