Precision of attenuation coefficient measurements by optical coherence tomography

Linda Neubrand; Ton van Leeuwen; Dirk Faber

doi:10.1117/12.2651779

9 March 2023 Precision of attenuation coefficient measurements by optical coherence tomography

Linda Neubrand, Ton van Leeuwen, Dirk Faber

Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC123670Y (2023) https://doi.org/10.1117/12.2651779
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

OCT is a non-contact interferometric imaging modality, which allows, next to visualization, quantification of tissue optical properties, yielding desired information about structure and organization of tissue. To date, no rigorous and standardized means for computing the precision of OCT-derived optical tissue properties has been proposed. Here, in our investigation, we develop a theoretical framework providing the lower bound for the precision of OCT-derived attenuation coefficients. Furthermore, in order to ensure clinical relevance of our framework, we derive and validate an analytical equation for this lower bound, providing a fast, rigorous and easy-to-use approach for commonly used OCT systems.

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Linda Neubrand, Ton van Leeuwen, and Dirk Faber "Precision of attenuation coefficient measurements by optical coherence tomography", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC123670Y (9 March 2023); https://doi.org/10.1117/12.2651779

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KEYWORDS

Signal attenuation

Optical coherence tomography

Signal to noise ratio

Optical testing

Computer simulations

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