Long-term photobiomodulation on mitochondrial activities of IMR-32 cells at 810nm

Huai-Ching Hsieh; Yi-Ju Lee; Kung-Bin Sung; An-Chi Wei

doi:10.1117/12.2646682

17 March 2023 Long-term photobiomodulation on mitochondrial activities of IMR-32 cells at 810nm

Huai-Ching Hsieh, Yi-Ju Lee, Kung-Bin Sung, An-Chi Wei

Proceedings Volume PC12362, Mechanisms of Photobiomodulation Therapy XVII; PC123620B (2023) https://doi.org/10.1117/12.2646682
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The long-term photobiomodulation of 810 nm LED light on the IMR-32 human neuroblastoma cell line was investigated. Daily light treatments of 1.26 J/cm2 and 1.755 J/cm2 both increase resistance to doxorubicin, sodium azide, and FCCP toxicity. However, 1.26 J/cm2 increases the mitochondrial DNA copy number, alters cell cycle-related pathways’ RNA expression, and promotes cell division. Operating differently, 1.755 J/cm2 decreases the mitochondrial DNA copy number and activates the oxidative phosphorylation pathway at the RNA, protein, and functional levels. The 810 nm light treatment shows two different long-term dose-dependent effects on cellular and mitochondrial activities.

Conference Presentation

Citation Download Citation

Huai-Ching Hsieh, Yi-Ju Lee, Kung-Bin Sung, and An-Chi Wei "Long-term photobiomodulation on mitochondrial activities of IMR-32 cells at 810nm", Proc. SPIE PC12362, Mechanisms of Photobiomodulation Therapy XVII, PC123620B (17 March 2023); https://doi.org/10.1117/12.2646682

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