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17 March 2023 Microlaser contractility sensing: a new approach for biomechanical sensing deep inside the beating heart
Marcel Schubert, Soraya Caixeiro, Vera Titze, Amy Dorward, Samantha Pitt, Malte Gather
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Proceedings Volume PC12355, Diagnostic and Therapeutic Applications of Light in Cardiology 2023; PC123550B (2023) https://doi.org/10.1117/12.2649706
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Sensing cardiac contractility on the single cell level and deep inside the heart remains a challenging task. Here, we interface microscopic whispering gallery mode lasers with cardiac cells and tissue to extract contractility profiles with cellular resolution and high temporal dynamics. To demonstrate advantages over imaging-based approaches, we characterise cardiac contractility in vivo in zebrafish embryos and in thick cardiac slices. We further present the development of nanolasers with improved spectral characteristics for sub-cellular sensing. Finally, we present new microlasers that extend the range of detectable biomechanical parameters, opening new avenues for future applications of microlasers in cardiovascular research.
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Marcel Schubert, Soraya Caixeiro, Vera Titze, Amy Dorward, Samantha Pitt, and Malte Gather "Microlaser contractility sensing: a new approach for biomechanical sensing deep inside the beating heart", Proc. SPIE PC12355, Diagnostic and Therapeutic Applications of Light in Cardiology 2023, PC123550B (17 March 2023); https://doi.org/10.1117/12.2649706
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KEYWORDS
Biosensing
Heart
Tissue optics
Signal detection
Laser tissue interaction
Particles
Photonics
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