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Self-assembled monolayer composed of metal nanoparticles is regarded as a metasurface that has high refractive index and extinction coefficient due to collective excitation of coupled LSPR. This plasmonic metasurface which confines light at the nanointerface and enhanced fluorescence allows a high-speed interfacial imaging with high axial and lateral resolution down to theoretical limit. In this presentation, we will report unique cell dynamics as “early molecular events” at the cell attached nanointerface using this imaging method.
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