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30 May 2022 A new approach to quantitative SERS with high sensitivity: vertical gap control
Samir Adhikari, Minjun Kim, Jongmin Lee, Yudong Jang, Donghan Lee
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Proceedings Volume PC12145, Biophotonics in Point-of-Care II; PC1214506 (2022) https://doi.org/10.1117/12.2622200
Event: SPIE Photonics Europe, 2022, Strasbourg, France
Abstract
Surface-enhanced Raman scattering (SERS) sensors, although label-free and extremely sensitive, are still not reproducible and not uniform enough for practical adoption. We propose an unique approach to quantitative SERS sensors satisfies all the sought-after characteristics: a SERS substrate that is uniform, reproducible, sensitive, large, and cost-effective. Specifically, we achieve a sensing uniformity of 4.2% averaged over 4 points and 2.3% over 16 points throughout the entire 6” substrate, and a SERS enhancement of 4.6x108. SERS spectra from four DNA bases are measured and their corresponding peaks are well defined down to 10 pM concentration.
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Samir Adhikari, Minjun Kim, Jongmin Lee, Yudong Jang, and Donghan Lee "A new approach to quantitative SERS with high sensitivity: vertical gap control", Proc. SPIE PC12145, Biophotonics in Point-of-Care II, PC1214506 (30 May 2022); https://doi.org/10.1117/12.2622200
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KEYWORDS
Sensors
Active remote sensing
Control systems
Raman scattering
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