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4 April 2022 Imaging of prostate cancer with 3D ultrasound tomography
James W. Wiskin, Jacob Enders, Cheyenne Williams, Ismail Turkbey M.D., Michael Rothberg M.D., Michael Daneshvar M.D., Maria Merino, Sheng Xu, Emad Boctor, Yixuan Wu, Antoun Toubaji, Ayele Negussie, John Klock, Brad Wood M.D., Peter Pinto M.D.
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Proceedings Volume PC12038, Medical Imaging 2022: Ultrasonic Imaging and Tomography; PC1203809 (2022) https://doi.org/10.1117/12.2611811
Event: SPIE Medical Imaging, 2022, San Diego, California, United States
Abstract
Prostate ultrasound imaging has utilized B-mode, however recent success in 3D ultrasound tomography (3D-UT) in the presence of bone, indicate using it to augment other potentially harmful or expensive modalities in clinic. Several fresh whole prostates were excised/inserted into bespoke polyacrylamide gel phantoms within 30 minutes of prostatectomy and scanned in the QT imaging scanner. The speed of sound (SOS) map resulting from the 3D-UT was used to create the refraction corrected reflection image compounded over 360 degrees resulting in sub-mm resolution. Several lesions were correlated with rigid transformations via anatomic landmarks with clinical MRI and H&E stained whole sections by experts in MRI and whole sectioning. Lesions were pointed out all 3 modalities and compared for multiple lesions indicating proof of concept of unique visibility of prostate lesions in 3D-UT (also volography) ex-vivo.
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James W. Wiskin, Jacob Enders, Cheyenne Williams, Ismail Turkbey M.D., Michael Rothberg M.D., Michael Daneshvar M.D., Maria Merino, Sheng Xu, Emad Boctor, Yixuan Wu, Antoun Toubaji, Ayele Negussie, John Klock, Brad Wood M.D., and Peter Pinto M.D. "Imaging of prostate cancer with 3D ultrasound tomography", Proc. SPIE PC12038, Medical Imaging 2022: Ultrasonic Imaging and Tomography, PC1203809 (4 April 2022); https://doi.org/10.1117/12.2611811
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KEYWORDS
3D image processing
Ultrasound tomography
Prostate cancer
Prostate
Magnetic resonance imaging
Bone
Image resolution
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