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4 March 2022 Real-time monitoring of bioactive coating growth by means of Bloch surface wave biosensors
Alberto Sinibaldi, Vanessa Montano-Machado, Norbert Danz, Peter Munzert, Francesco Chiavaioli, Diego Mantovani, Francesco Michelotti
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Proceedings Volume PC11979, Frontiers in Biological Detection: From Nanosensors to Systems XIV; PC1197908 (2022) https://doi.org/10.1117/12.2623478
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
The study of the interaction of fibronectin and phosphorylcholine molecules with surfaces is of high relevance to understand the biological performance of bioactive coatings. To accomplish this task, one-dimensional photonic crystals supporting Bloch surface waves were interrogated in label-free and enhanced fluorescence operation modes. In particular, the enhanced fluorescence mode offers the possibility to confirm the presence of proteins with a sharp improvement of the resolution. Bioactive coatings based on fibronectin/ phosphorylcholine have thus the potential to not only enhance the body acceptance of implanted devices, but also extend the lifetime of such devices.
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Alberto Sinibaldi, Vanessa Montano-Machado, Norbert Danz, Peter Munzert, Francesco Chiavaioli, Diego Mantovani, and Francesco Michelotti "Real-time monitoring of bioactive coating growth by means of Bloch surface wave biosensors", Proc. SPIE PC11979, Frontiers in Biological Detection: From Nanosensors to Systems XIV, PC1197908 (4 March 2022); https://doi.org/10.1117/12.2623478
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KEYWORDS
Coating
Biosensors
Luminescence
Proteins
Molecules
Photonic crystals
Prisms
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