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3 March 2022 Designing biodegradable inorganic nanoparticles for optical applications in biomedicine
Allison M. Dennis
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Proceedings Volume PC11977, Colloidal Nanoparticles for Biomedical Applications XVII; PC119770E (2022) https://doi.org/10.1117/12.2610403
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
The biodegradation and excretion of biocompatible semiconductor nanoparticles could avoid problematic bioaccumulation and enable translational applications that utilize their unique optoelectronic properties. Through our studies of ternary copper sulfide-based nanoparticles, we have identified compositions that exhibit useful optical properties while also degrading into benign, bioessential components. Comparison to toxic compositions provides insight into the structure-function relationship between composition, degradation rate, and toxicity. Considering biocompatibility even before the optical properties are optimized ensures that development favors compositions that are most appropriate for longitudinal in vivo studies.
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Allison M. Dennis "Designing biodegradable inorganic nanoparticles for optical applications in biomedicine", Proc. SPIE PC11977, Colloidal Nanoparticles for Biomedical Applications XVII, PC119770E (3 March 2022); https://doi.org/10.1117/12.2610403
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KEYWORDS
Nanoparticles
Biomedical optics
Copper
Particles
Toxicity
Copper indium disulfide
Indium
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