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2 March 2022 Bond-selective intensity diffraction tomography
Jian Zhao, Alex Matlock, Ziqi Song, Jiabei Zhu, Fukai Chen, Yuewei Zhan, Zhicong Chen, Xingchen Lin, Hongbo Zhu, Lei Tian, Ji-Xin Cheng
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Proceedings Volume PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022; PC119730F (2022) https://doi.org/10.1117/12.2607981
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Volumetric chemical imaging is highly desired for investigating biochemical processes at the sub-cellular level. Here, we report bond-selective intensity diffraction tomography (BS-IDT) based on 3D quantitative phase detection of the mid-infrared photothermal effect. BS-IDT demonstrates volumetric chemical imaging with incoherent diffraction-limited resolution and a high speed up to ~6 Hz per volume. The mid-IR spectrum extracted from BS-IDT shows high fidelity compared with ground truth measured by an FTIR spectrometer. The 3D chemical imaging results from cancer cells and Caenorhabditis elegans validate BS-IDT’s superior performance.
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Jian Zhao, Alex Matlock, Ziqi Song, Jiabei Zhu, Fukai Chen, Yuewei Zhan, Zhicong Chen, Xingchen Lin, Hongbo Zhu, Lei Tian, and Ji-Xin Cheng "Bond-selective intensity diffraction tomography", Proc. SPIE PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022, PC119730F (2 March 2022); https://doi.org/10.1117/12.2607981
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KEYWORDS
Diffraction
Tomography
Imaging spectroscopy
Imaging systems
Spectroscopy
Cancer
Mid-IR
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