Development and characterization of a disposable sub-millimeter fiberoptic Raman needle probe for real-time deep tissue and biofluids Raman measurements

Chi Shu; Wei Zheng; Zhuo Wang; Changyuan Yu; Zhiwei Huang

doi:10.1117/12.2614404

7 March 2022 Development and characterization of a disposable sub-millimeter fiberoptic Raman needle probe for real-time deep tissue and biofluids Raman measurements

Chi Shu, Wei Zheng, Zhuo Wang, Changyuan Yu, Zhiwei Huang

Author Affiliations +

Proceedings Volume PC11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry; PC119570F (2022) https://doi.org/10.1117/12.2614404
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We develop a disposable sub-millimeter fiberoptic Raman needle probe for real-time in vivo tissue and biofluids Raman measurements. High-quality tissue Raman spectra in fingerprint and high-wavenumber regions can be collected within sub-second from different tissue types and biofluids using the needle Raman probe fabricated together with the structured background subtraction algorithm developed. We further validate the depth-resolved deep tissue Raman spectra measurement capability of the fiberoptic needle Raman probe by advancing the needle Raman probe into a mice brain model. We demonstrate that the sub-millimeter fiberoptic Raman probe developed can achieve real-time time collection of deep tissue and biofluids FP/HW Raman spectra with high signal to noise ratios, suggesting the potential of dual functioning of Raman optical biopsy and fine-needle aspiration biopsy for in vivo deep tissue and biofluids characterization in the human body.

Conference Presentation

Citation Download Citation

Chi Shu, Wei Zheng, Zhuo Wang, Changyuan Yu, and Zhiwei Huang "Development and characterization of a disposable sub-millimeter fiberoptic Raman needle probe for real-time deep tissue and biofluids Raman measurements", Proc. SPIE PC11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, PC119570F (7 March 2022); https://doi.org/10.1117/12.2614404

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KEYWORDS

Raman spectroscopy

Fiber optics

Tissues

Fiber optics tests

Tissue optics

Algorithm development

Biopsy

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