The earlier the better: instantaneous cutaneous concentration quantification at the time of application

Avery Goss; Benjamin A Kuzma; Conor L. Evans

doi:10.1117/12.2608673

7 March 2022 The earlier the better: instantaneous cutaneous concentration quantification at the time of application

Avery Goss, Benjamin A Kuzma, Conor L. Evans

Proceedings Volume PC11938, Visualizing and Quantifying Drug Distribution in Tissue VI; PC119380C (2022) https://doi.org/10.1117/12.2608673
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Cutaneous pharmacokinetics (cPK) can be quantified utilizing a myriad of in vitro and in vivo approaches. However, these techniques provide macroscale cPK for long experimental durations and do not provide cPK information from the moments directly after a topical formulation application, thus missing critical product dosing insight. Furthermore, formulations are typically applied for 5-10 minutes in the clinic and then removed (purposely or accidentally), which requires a high temporal and spatial resolution estimate of the early timepoint cPK. We have developed a 3-D printed applicator to address the unmet need for early time-point cPK quantification pertinent to the clinic.

Conference Presentation

Citation Download Citation

Avery Goss, Benjamin A Kuzma, and Conor L. Evans "The earlier the better: instantaneous cutaneous concentration quantification at the time of application", Proc. SPIE PC11938, Visualizing and Quantifying Drug Distribution in Tissue VI, PC119380C (7 March 2022); https://doi.org/10.1117/12.2608673

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