Characterizing subepithelial remodeling in eosinophilic esophagitis with PS-μOCT

Conor J. Sheil; Andreas Wartak; Joseph A. Gardecki; Abigail L Gregg; Guillermo J. Tearney

doi:10.1117/12.2609948

7 March 2022 Characterizing subepithelial remodeling in eosinophilic esophagitis with PS-μOCT

Conor J. Sheil, Andreas Wartak, Joseph A. Gardecki, Abigail L Gregg, Guillermo J. Tearney

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Proceedings Volume PC11937, Endoscopic Microscopy XVII; PC119370J (2022) https://doi.org/10.1117/12.2609948
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Eosiophilic esophagitis (EoE) is an inflammatory disease of the esophagus, with long-term EoE causing fibrotic and hypertrophic restructuring of the sub-epithelial wall. We have developed a polarization-sensitive micro-optical coherence tomography (PS-µOCT) imaging device for its characterization. This device was used to quantify collagen at 15 sites on each of 5 swine esophagi, with results compared to histology. A linear mixed model with random intercept showed significant agreement between OCT and histology (slope = 0.41, 95% CI [0.22, 0.60], t(67) = 4.30, p = 5.8 x 10-5). This validates our technology and will allow longitudinal assessment of patient response to drug and diet, without endoscopic biopsy.

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Citation Download Citation

Conor J. Sheil, Andreas Wartak, Joseph A. Gardecki, Abigail L Gregg, and Guillermo J. Tearney "Characterizing subepithelial remodeling in eosinophilic esophagitis with PS-μOCT", Proc. SPIE PC11937, Endoscopic Microscopy XVII, PC119370J (7 March 2022); https://doi.org/10.1117/12.2609948

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KEYWORDS

Collagen

Esophagus

Biopsy

Endoscopy

Microscopy

Optical coherence tomography

Statistical modeling

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