Quantitative analysis of the polarization characteristics of atherosclerotic plaques

Ekaterina V. Gubarkova; Michail Yu. Kirillin; Varvara V. Dudenkova; Elena B. Kiseleva; Alexander A. Moiseev; Grigory V. Gelikonov; Lidia B. Timofeeva; Ilya I. Fiks; Felix I. Feldchtein; Natalia D. Gladkova

doi:10.1117/12.2227477

27 April 2016 Quantitative analysis of the polarization characteristics of atherosclerotic plaques

Ekaterina V. Gubarkova, Michail Yu. Kirillin, Varvara V. Dudenkova, Elena B. Kiseleva, Alexander A. Moiseev, Grigory V. Gelikonov, Lidia B. Timofeeva, Ilya I. Fiks, Felix I. Feldchtein, Natalia D. Gladkova

Author Affiliations +

Proceedings Volume 9887, Biophotonics: Photonic Solutions for Better Health Care V; 988736 (2016) https://doi.org/10.1117/12.2227477
Event: SPIE Photonics Europe, 2016, Brussels, Belgium

Abstract

In this study we demonstrate the capability of cross-polarization optical coherence tomography (CP OCT) to assess collagen and elastin fibers condition in atherosclerotic plaques basing on ratio of the OCT signal levels in cross- and со- polarizations. We consider the depolarization factor (DF) and the effective birefringence (Δn) as quantitative characteristics of CP OCT images. We revealed that calculation of both DF and Δn in the region of interest (fibrous cap) yields a statistically significant difference between stable and unstable plaques (0.46±0.21 vs 0.09±0.04 for IDF; (4.7±1.0)•10^–4 vs (2.5±0.7)•10^–4 for Δn; p<0.05). In parallel with CP OCT we used the nonlinear microscopy for analysis of thin cross-section of atherosclerotic plaque, revealing the different average isotropy index of collagen and elastin fibers for stable and unstable plaques (0.30 ± 0.10 vs 0.70 ± 0.08; р<0.001). The proposed approach for quantitative assessment of CP OCT images allows cross-scattering and birefringence characterization of stable and unstable atherosclerotic plaques.

Citation Download Citation

Ekaterina V. Gubarkova, Michail Yu. Kirillin, Varvara V. Dudenkova, Elena B. Kiseleva, Alexander A. Moiseev, Grigory V. Gelikonov, Lidia B. Timofeeva, Ilya I. Fiks, Felix I. Feldchtein, and Natalia D. Gladkova "Quantitative analysis of the polarization characteristics of atherosclerotic plaques", Proc. SPIE 9887, Biophotonics: Photonic Solutions for Better Health Care V, 988736 (27 April 2016); https://doi.org/10.1117/12.2227477

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available