Blood proteins analysis by Raman spectroscopy method

D. N. Artemyev; I. A. Bratchenko; Yu. A. Khristoforova; A. A. Lykina; O. O. Myakinin; T. P. Kuzmina; I. L. Davydkin; V. P. Zakharov

doi:10.1117/12.2227906

28 April 2016 Blood proteins analysis by Raman spectroscopy method

D. N. Artemyev, I. A. Bratchenko, Yu. A. Khristoforova, A. A. Lykina, O. O. Myakinin, T. P. Kuzmina, I. L. Davydkin, V. P. Zakharov

Author Affiliations +

Proceedings Volume 9887, Biophotonics: Photonic Solutions for Better Health Care V; 98871Y (2016) https://doi.org/10.1117/12.2227906
Event: SPIE Photonics Europe, 2016, Brussels, Belgium

Abstract

This work is devoted to study the possibility of plasma proteins (albumin, globulins) concentration measurement using Raman spectroscopy setup. The blood plasma and whole blood were studied in this research. The obtained Raman spectra showed significant variation of intensities of certain spectral bands 940, 1005, 1330, 1450 and 1650 cm^-1 for different protein fractions. Partial least squares regression analysis was used for determination of correlation coefficients. We have shown that the proposed method represents the structure and biochemical composition of major blood proteins.

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D. N. Artemyev, I. A. Bratchenko, Yu. A. Khristoforova, A. A. Lykina, O. O. Myakinin, T. P. Kuzmina, I. L. Davydkin, and V. P. Zakharov "Blood proteins analysis by Raman spectroscopy method", Proc. SPIE 9887, Biophotonics: Photonic Solutions for Better Health Care V, 98871Y (28 April 2016); https://doi.org/10.1117/12.2227906

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