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27 April 2016 What advances in microscopy are required for combined MRI and optical functional brain imaging? (Conference Presentation)
David Kleinfeld
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Proceedings Volume 9717, Adaptive Optics and Wavefront Control for Biological Systems II; 97170D (2016) https://doi.org/10.1117/12.2218121
Event: SPIE BiOS, 2016, San Francisco, California, United States
Abstract
This overview talk will focus on forward-looking scientific needs and physical limits to images of neuronal processes. The challenge in nervous systems is that the basic unit for "switching" events in the nervous system occurs on the one micrometer scale of synaptic spines, while computations involve communication between individual neurons across the full expanse of cortex, which is ten millimeters for mouse cortex. I will address hoped-for advances in optical microscopy, within the context of existing and proposed contrast mechanisms of neuronal function, that span the four orders of magnitude of length scales for neuronal processing
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View presentation recording on the SPIE Digital Library: http://dx.doi.org/10.1117/12.2218121.4848767664001
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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David Kleinfeld "What advances in microscopy are required for combined MRI and optical functional brain imaging? (Conference Presentation)", Proc. SPIE 9717, Adaptive Optics and Wavefront Control for Biological Systems II, 97170D (27 April 2016); https://doi.org/10.1117/12.2218121
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KEYWORDS
Brain imaging
Magnetic resonance imaging
Microscopy
Nervous system
Image processing
Neurons
Optical microscopy
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