Characterization of red blood cells (RBCs) using dual Brillouin/Raman micro-spectroscopy

Zhaokai Meng; Sandra C. Bustamante-Lopez; Vladislav V. Yakovlev; Kenith E. Meissner II

doi:10.1117/12.2213640

6 April 2016 Characterization of red blood cells (RBCs) using dual Brillouin/Raman micro-spectroscopy

Zhaokai Meng, Sandra C. Bustamante-Lopez, Vladislav V. Yakovlev, Kenith E. Meissner II

Proceedings Volume 9711, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX; 97110M (2016) https://doi.org/10.1117/12.2213640
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Erythrocytes, or red blood cells, transport oxygen to and carbon dioxide from the body's tissues and organs. Red blood cell mechanical properties are altered in a number of diseases such as sickle cell anaemia and malaria. Additionally, mechanically modified red blood cell ghosts are being considered as a long-term, biocompatible carrier for drug delivery and for blood analyte sensing. Brillouin spectroscopy enables viscoelastic characterization of samples at the microscale. In this report, Brillouin spectroscopy is applied to characterize the mechanical properties of red blood cells and red blood cell ghosts.

Citation Download Citation

Zhaokai Meng, Sandra C. Bustamante-Lopez, Vladislav V. Yakovlev, and Kenith E. Meissner II "Characterization of red blood cells (RBCs) using dual Brillouin/Raman micro-spectroscopy", Proc. SPIE 9711, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, 97110M (6 April 2016); https://doi.org/10.1117/12.2213640

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