Modular microfluidic cartridge-based universal diagnostic system for global health applications

Holger Becker; Richard Klemm; William Dietze; Wallace White; Nadine Hlawatsch; Susanne Freyberg; Christian Moche; Peter Dailey; Claudia Gärtner

doi:10.1117/12.2217892

18 March 2016 Modular microfluidic cartridge-based universal diagnostic system for global health applications

Holger Becker, Richard Klemm, William Dietze, Wallace White, Nadine Hlawatsch, Susanne Freyberg, Christian Moche, Peter Dailey, Claudia Gärtner

Author Affiliations +

Proceedings Volume 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV; 970514 (2016) https://doi.org/10.1117/12.2217892
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Current microfluidics-enabled point-of-care diagnostic systems are typically designed specifically for one assay type, e.g. a molecular diagnostic assay for a single disease of a class of diseases. This approach often leads to high development cost and a significant training requirement for users of different instruments. We have developed an open platform diagnostic system which allows to run molecular, immunological and clinical assays on a single instrument platform with a standardized microfluidic cartridge architecture in an automated sample-in answer-out fashion. As examples, a molecular diagnostic assay for tuberculosis, an immunoassay for HIV p24 and a clinical chemistry assay for ALT liver function have been developed and results of their pre-clinical validation are presented.

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Citation Download Citation

Holger Becker, Richard Klemm, William Dietze, Wallace White, Nadine Hlawatsch, Susanne Freyberg, Christian Moche, Peter Dailey, and Claudia Gärtner "Modular microfluidic cartridge-based universal diagnostic system for global health applications", Proc. SPIE 9705, Microfluidics, BioMEMS, and Medical Microsystems XIV, 970514 (18 March 2016); https://doi.org/10.1117/12.2217892

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