Development and clinical translation of OTIS: a wide-field OCT imaging device for ex-vivo tissue characterization

Elizabeth A. Munro; David Rempel; Christine Danner; Yaaseen Atchia; Michael S. Valic; Andrew Berkeley; Bahar Davoudi; Paul A. Magnin; Margarete Akens; Susan J. Done; Supriya Kulkarni; Wey-Liang Leong; Brian C. Wilson

doi:10.1117/12.2218467

7 March 2016 Development and clinical translation of OTIS: a wide-field OCT imaging device for ex-vivo tissue characterization

Elizabeth A. Munro, David Rempel, Christine Danner, Yaaseen Atchia, Michael S. Valic, Andrew Berkeley, Bahar Davoudi, Paul A. Magnin, Margarete Akens, Susan J. Done, Supriya Kulkarni, Wey-Liang Leong, Brian C. Wilson

Author Affiliations +

Proceedings Volume 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis; 97030L (2016) https://doi.org/10.1117/12.2218467
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We have developed an automated, wide-field optical coherence tomography (OCT)-based imaging device (OTIS^TM Perimeter Medical Imaging) for peri-operative, ex-vivo tissue imaging. This device features automated image acquisition, enabling rapid capture of high-resolution (15 μm) OCT images from samples up to 10 cm in diameter. We report on the iterative progression of device development from phantom and pre-clinical (tumor xenograft) models through to initial clinical results. We discuss the challenges associated with proving a novel imaging technology against the clinical “gold standard” of conventional post-operative pathology.

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Elizabeth A. Munro, David Rempel, Christine Danner, Yaaseen Atchia, Michael S. Valic, Andrew Berkeley, Bahar Davoudi, Paul A. Magnin, Margarete Akens, Susan J. Done, Supriya Kulkarni, Wey-Liang Leong, and Brian C. Wilson "Development and clinical translation of OTIS: a wide-field OCT imaging device for ex-vivo tissue characterization", Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 97030L (7 March 2016); https://doi.org/10.1117/12.2218467

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