LED induced autofluorescence (LIAF) imager with eight multi-filters for oral cancer diagnosis

Ting-Wei Huang; Nai-Lun Cheng; Ming-Hsui Tsai; Jin-Chern Chiou; Ou-Yang Mang

doi:10.1117/12.2212836

18 March 2016 LED induced autofluorescence (LIAF) imager with eight multi-filters for oral cancer diagnosis

Ting-Wei Huang, Nai-Lun Cheng, Ming-Hsui Tsai, Jin-Chern Chiou, Ou-Yang Mang

Proceedings Volume 9700, Design and Quality for Biomedical Technologies IX; 97000W (2016) https://doi.org/10.1117/12.2212836
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Oral cancer is one of the serious and growing problem in many developing and developed countries. The simple oral visual screening by clinician can reduce 37,000 oral cancer deaths annually worldwide. However, the conventional oral examination with the visual inspection and the palpation of oral lesions is not an objective and reliable approach for oral cancer diagnosis, and it may cause the delayed hospital treatment for the patients of oral cancer or leads to the oral cancer out of control in the late stage. Therefore, a device for oral cancer detection are developed for early diagnosis and treatment. A portable LED Induced autofluorescence (LIAF) imager is developed by our group. It contained the multiple wavelength of LED excitation light and the rotary filter ring of eight channels to capture ex-vivo oral tissue autofluorescence images. The advantages of LIAF imager compared to other devices for oral cancer diagnosis are that LIAF imager has a probe of L shape for fixing the object distance, protecting the effect of ambient light, and observing the blind spot in the deep port between the gumsgingiva and the lining of the mouth. Besides, the multiple excitation of LED light source can induce multiple autofluorescence, and LIAF imager with the rotary filter ring of eight channels can detect the spectral images of multiple narrow bands. The prototype of a portable LIAF imager is applied in the clinical trials for some cases in Taiwan, and the images of the clinical trial with the specific excitation show the significant differences between normal tissue and oral tissue under these cases.

Citation Download Citation

Ting-Wei Huang, Nai-Lun Cheng, Ming-Hsui Tsai, Jin-Chern Chiou, and Ou-Yang Mang "LED induced autofluorescence (LIAF) imager with eight multi-filters for oral cancer diagnosis", Proc. SPIE 9700, Design and Quality for Biomedical Technologies IX, 97000W (18 March 2016); https://doi.org/10.1117/12.2212836

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Cancer

Light emitting diodes

Imaging systems

Image filtering

Tissues

Clinical trials

Bandpass filters

Show All Keywords

Keywords/Phrases

Search In:

Publication Years