Digital detection of biomarkers for high-sensitivity diagnostics at low-cost

M. Selim Ünlü; John Connor; Steve Scherr; George G. Daaboul; Elif Ç. Seymour; Nese Lortlar Ünlü; Jacob Trueb; Derin D. Sevenler; Oguzhan Avci

doi:10.1117/12.2218530

11 March 2016 Digital detection of biomarkers for high-sensitivity diagnostics at low-cost

M. Selim Ünlü, John Connor, Steve Scherr, George G. Daaboul, Elif Ç. Seymour, Nese Lortlar Ünlü, Jacob Trueb, Derin D. Sevenler, Oguzhan Avci

Author Affiliations +

Proceedings Volume 9699, Optics and Biophotonics in Low-Resource Settings II; 969902 (2016) https://doi.org/10.1117/12.2218530
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We have demonstrated Interferometric Reflectance Imaging Sensor (IRIS) with the ability to detect single nanoscale particles. By extending single-particle IRIS to in-liquid dynamic imaging, we demonstrated real-time digital detection of individual viral pathogens as well as single molecules labeled with Au nanoparticles. With this technique we demonstrate real-time simultaneous detection of multiple targets in a single sample, as well as quantitative dynamic detection of individual biomolecular interactions for reaction kinetics measurements. This approach promises to simplify and reduce the cost of rapid diagnostics.

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M. Selim Ünlü, John Connor, Steve Scherr, George G. Daaboul, Elif Ç. Seymour, Nese Lortlar Ünlü, Jacob Trueb, Derin D. Sevenler, and Oguzhan Avci "Digital detection of biomarkers for high-sensitivity diagnostics at low-cost", Proc. SPIE 9699, Optics and Biophotonics in Low-Resource Settings II, 969902 (11 March 2016); https://doi.org/10.1117/12.2218530

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