In vivo imaging of pulmonary nodule and vasculature using endoscopic co-registered optical coherence tomography and autofluorescence imaging (Conference Presentation)

Hamid Pahlevaninezhad; Anthony Lee M.D.; Geoffrey Hohert; Carely Schwartz; Tawimas Shaipanich M.D.; Alexander J. Ritchie; Wei Zhang M.D.; Calum E. MacAulay; Stephen Lam M.D.; Pierre M. Lane

doi:10.1117/12.2209686

27 April 2016 In vivo imaging of pulmonary nodule and vasculature using endoscopic co-registered optical coherence tomography and autofluorescence imaging (Conference Presentation)

Hamid Pahlevaninezhad, Anthony Lee M.D., Geoffrey Hohert, Carely Schwartz, Tawimas Shaipanich M.D., Alexander J. Ritchie, Wei Zhang M.D., Calum E. MacAulay, Stephen Lam M.D., Pierre M. Lane

Author Affiliations +

Proceedings Volume 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III; 96910Y (2016) https://doi.org/10.1117/12.2209686
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Peripheral lung nodules found by CT-scans are difficult to localize and biopsy bronchoscopically particularly for those ≤ 2 cm in diameter. In this work, we present the results of endoscopic co-registered optical coherence tomography and autofluorescence imaging (OCT-AFI) of normal and abnormal peripheral airways from 40 patients using 0.9 mm diameter fiber optic rotary pullback catheter. Optical coherence tomography (OCT) can visualize detailed airway morphology endoscopically in the lung periphery. Autofluorescence imaging (AFI) can visualize fluorescing tissue components such as collagen and elastin, enabling the detection of airway lesions with high sensitivity. Results indicate that AFI of abnormal airways is different from that of normal airways, suggesting that AFI can provide a sensitive visual presentation for rapidly identifying possible sites of pulmonary nodules. AFI can also rapidly visualize in vivo vascular networks using fast scanning parameters resulting in vascular-sensitive imaging with less breathing/cardiac motion artifacts compared to Doppler OCT imaging. It is known that tumor vasculature is structurally and functionally different from normal vessels. Thus, AFI can be potentially used for differentiating normal and abnormal lung vasculature for studying vascular remodeling.

Conference Presentation

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Hamid Pahlevaninezhad, Anthony Lee M.D., Geoffrey Hohert, Carely Schwartz, Tawimas Shaipanich M.D., Alexander J. Ritchie, Wei Zhang M.D., Calum E. MacAulay, Stephen Lam M.D., and Pierre M. Lane "In vivo imaging of pulmonary nodule and vasculature using endoscopic co-registered optical coherence tomography and autofluorescence imaging (Conference Presentation)", Proc. SPIE 9691, Endoscopic Microscopy XI; and Optical Techniques in Pulmonary Medicine III, 96910Y (27 April 2016); https://doi.org/10.1117/12.2209686

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KEYWORDS

Optical coherence tomography

Auto-fluorescence imaging

Visualization

Endoscopy

In vivo imaging

Lung

Biopsy

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