NIRS-based noninvasive cerebrovascular regulation assessment

S. Miller; I. Richmond; J. Borgos; K. Mitra

doi:10.1117/12.2213951

9 March 2016 NIRS-based noninvasive cerebrovascular regulation assessment

S. Miller, I. Richmond, J. Borgos, K. Mitra

Proceedings Volume 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation; 96900W (2016) https://doi.org/10.1117/12.2213951
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Alterations to cerebral blood flow (CBF) have been implicated in diverse neurological conditions, including mild traumatic brain injury, microgravity induced intracranial pressure (ICP) increases, mild cognitive impairment, and Alzheimer’s disease. Near infrared spectroscopy (NIRS)-measured regional cerebral tissue oxygen saturation (rSO2) provides an estimate of oxygenation of the interrogated cerebral volume that is useful in identifying trends and changes in oxygen supply to cerebral tissue and has been used to monitor cerebrovascular function during surgery and ventilation. In this study, CO₂-inhalation-based hypercapnic breathing challenges were used as a tool to simulate CBF dysregulation, and NIRS was used to monitor the CBF autoregulatory response. A breathing circuit for the selective administration of CO2-compressed air mixtures was designed and used to assess CBF regulatory responses to hypercapnia in 26 healthy young adults using non-invasive methods and real-time sensors. After a 5 or 10 minute baseline period, 1 to 3 hypercapnic challenges of 5 or 10 minutes duration were delivered to each subject while rSO₂, partial pressure of end tidal CO₂ (PETCO₂), and vital signs were continuously monitored. Change in rSO₂ measurements from pre- to intrachallenge (ΔrSO₂) detected periods of hypercapnic challenges. Subjects were grouped into three exercise factor levels (hr/wk), 1: 0, 2:>0 and <10, and 3:>10. Exercise factor level 3 subjects showed significantly greater ΔrSO₂ responses to CO₂ challenges than level 2 and 1 subjects. No significant difference in ΔPETCO2 existed between these factor levels. Establishing baseline values of rSO₂ in clinical practice may be useful in early detection of CBF changes.

Citation Download Citation

S. Miller, I. Richmond, J. Borgos, and K. Mitra "NIRS-based noninvasive cerebrovascular regulation assessment", Proc. SPIE 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 96900W (9 March 2016); https://doi.org/10.1117/12.2213951

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