Evaluation of spatially resolved diffuse reflectance imaging for subsurface pattern visualization towards applicability for fiber optic lensless imaging setup: phantom experiments and simulation

I. Schelkanova; A. Pandya; G. Saiko; L. Nacy; H. Babar; D. Shah; L. Lilge; A. Douplik

doi:10.1117/12.2183828

15 July 2015 Evaluation of spatially resolved diffuse reflectance imaging for subsurface pattern visualization towards applicability for fiber optic lensless imaging setup: phantom experiments and simulation

I. Schelkanova, A. Pandya, G. Saiko, L. Nacy, H. Babar, D. Shah, L. Lilge, A. Douplik

Author Affiliations +

Proceedings Volume 9537, Clinical and Biomedical Spectroscopy and Imaging IV; 95371T (2015) https://doi.org/10.1117/12.2183828
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

A portable, spatially resolved diffuse reflectance (SRDR) lensless imaging technique based on the charge coupled device (CCD), or complementary metal-oxide semiconductor (CMOS) sensor directly coupled with fiber optic bundle can be proposed for visualization of subsurface structures such as intrapapillary capillary loops (IPCLs). In this article, we discuss an experimental method for emulating a lensless imaging setup via raster scanning a single fiberoptic cable (where image is relayed onto the sensor surface through a fiber-optic cable equivalent to coupling a fiber optic conduit directly onto the sensor surface without any lenses) over a microfluidic phantom containing periodic hemoglobin absorption contrast. For mimicking scattering properties of turbid media, a diffusive layer formed of polydimethylsiloxane (PDMS) and titanium dioxide (TiO2) was placed atop of the microfluidic phantom. Thickness of the layers ranged from 0.2-0.7mm, and the μs` value of the layers were in the range of 0.85 mm^-1 – 4.25mm^-1. The results demonstrate that a fiber-optic bundle/plate coupled lensless imaging setup has a high potential to recover intensity modulations from the subsurface patterns. Decreasing of the interrogation volumes leads to enhanced spatial resolution of diffuse reflectance imaging, and hence, can potentially overcome the scattering caused blurring.

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I. Schelkanova, A. Pandya, G. Saiko, L. Nacy, H. Babar, D. Shah, L. Lilge, and A. Douplik "Evaluation of spatially resolved diffuse reflectance imaging for subsurface pattern visualization towards applicability for fiber optic lensless imaging setup: phantom experiments and simulation", Proc. SPIE 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95371T (15 July 2015); https://doi.org/10.1117/12.2183828

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KEYWORDS

Scattering

Sensors

Fiber optics

Microfluidics

Diffuse reflectance spectroscopy

Visualization

Capillaries

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