Characterization of new drug delivery nanosystems using atomic force microscopy

Ellas Spyratou; Elena A. Mourelatou; C. Demetzos; Mersini Makropoulou; A. A. Serafetinides

doi:10.1117/12.2178483

8 January 2015 Characterization of new drug delivery nanosystems using atomic force microscopy

Ellas Spyratou, Elena A. Mourelatou, C. Demetzos, Mersini Makropoulou, A. A. Serafetinides

Proceedings Volume 9447, 18th International School on Quantum Electronics: Laser Physics and Applications; 944714 (2015) https://doi.org/10.1117/12.2178483
Event: Eighteenth International School on Quantum Electronics: Laser Physics and Applications, 2014, Sozopol, Bulgaria

Abstract

Liposomes are the most attractive lipid vesicles for targeted drug delivery in nanomedicine, behaving also as cell models in biophotonics research. The characterization of the micro-mechanical properties of drug carriers is an important issue and many analytical techniques are employed, as, for example, optical tweezers and atomic force microscopy. In this work, polyol hyperbranched polymers (HBPs) have been employed along with liposomes for the preparation of new chimeric advanced drug delivery nanosystems (Chi-aDDnSs). Aliphatic polyester HBPs with three different pseudogenerations G2, G3 and G4 with 16, 32, and 64 peripheral hydroxyl groups, respectively, have been incorporated in liposomal formulation. The atomic force microscopy (AFM) technique was used for the comparative study of the morphology and the mechanical properties of Chi-aDDnSs and conventional DDnS. The effects of both the HBPs architecture and the polyesters pseudogeneration number in the stability and the stiffness of chi-aDDnSs were examined. From the force-distance curves of AFM spectroscopy, the Young’s modulus was calculated.

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Ellas Spyratou, Elena A. Mourelatou, C. Demetzos, Mersini Makropoulou, and A. A. Serafetinides "Characterization of new drug delivery nanosystems using atomic force microscopy ", Proc. SPIE 9447, 18th International School on Quantum Electronics: Laser Physics and Applications, 944714 (8 January 2015); https://doi.org/10.1117/12.2178483

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