DNA origami based assembly of gold nanoparticle dimers for SERS detection

Vivek V. Thacker; Lars O. Herrmann; Daniel O. Sigle; Tao Zhang; Tim Liedl; Jeremy J. Baumberg; Ulrich F. Keyser

doi:10.1117/12.2076799

11 March 2015 DNA origami based assembly of gold nanoparticle dimers for SERS detection

Vivek V. Thacker, Lars O. Herrmann, Daniel O. Sigle, Tao Zhang, Tim Liedl, Jeremy J. Baumberg, Ulrich F. Keyser

Proceedings Volume 9340, Plasmonics in Biology and Medicine XII; 934002 (2015) https://doi.org/10.1117/12.2076799
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Plasmonic sensors are extremely promising candidates for label-free single molecule analysis but require exquisite control over the physical arrangement of metallic nanostructures. We employ self-assembly based on the DNA origami technique for accurate positioning of individual 40 nm gold nanoparticles with gaps of 3.3±1 nm. This is probed through far field scattering measurements on individual dimers. This plasmonic coupling allows us to use surface enhanced Raman scattering (SERS) to detect a small number of dye molecules as well as short single-stranded DNA oligonucleotides in the vicinity of the dimers. This demonstrates that DNA origami is a powerful tool with great potential for a wide variety of biosensing and single-molecule applications.

Citation Download Citation

Vivek V. Thacker, Lars O. Herrmann, Daniel O. Sigle, Tao Zhang, Tim Liedl, Jeremy J. Baumberg, and Ulrich F. Keyser "DNA origami based assembly of gold nanoparticle dimers for SERS detection", Proc. SPIE 9340, Plasmonics in Biology and Medicine XII, 934002 (11 March 2015); https://doi.org/10.1117/12.2076799

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available