Photo-nano immunotherapy for metastatic breast cancer using synergistic single-walled carbon nanotubes and glycated chitosan

Feifan Zhou; Aamr Hasanjee; Austin Doughty; Connor West; Hong Liu; Wei  R. Chen

doi:10.1117/12.2079378

9 March 2015 Photo-nano immunotherapy for metastatic breast cancer using synergistic single-walled carbon nanotubes and glycated chitosan

Feifan Zhou, Aamr Hasanjee, Austin Doughty, Connor West, Hong Liu, Wei R. Chen

Author Affiliations +

Proceedings Volume 9324, Biophotonics and Immune Responses X; 93240L (2015) https://doi.org/10.1117/12.2079378
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

In our previous work, we constructed a multifunctional nano system, using single-walled carbon nanotube (SWNT) and glycated chitosan (GC), which can synergize photothermal and immunological effects. To further confirm the therapy efficacy, with a metastatic mouse mammary tumor model (4T1), we investigate the therapy effects and immune response induced by SWNT-GC, under laser irradiation. Laser+SWNT-GC treatment not only suppressed the prime tumor, but also induced antitumor immune response. It could be developed into a promising treatment modality for the metastatic breast cancer.

Citation Download Citation

Feifan Zhou, Aamr Hasanjee, Austin Doughty, Connor West, Hong Liu, and Wei R. Chen "Photo-nano immunotherapy for metastatic breast cancer using synergistic single-walled carbon nanotubes and glycated chitosan", Proc. SPIE 9324, Biophotonics and Immune Responses X, 93240L (9 March 2015); https://doi.org/10.1117/12.2079378

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